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You will play a central role in the operation, scientific exploitation, and future development of the ID09 beamline. You will also actively contribute to the broader activities of the X-ray diffraction and scattering group at ESRF. User support is at the
Investigate and evaluate new sample preparation protocols for bottom-up proteomics, including protein digestion, peptide clean-up, enrichment of post-translationally modified peptides, and handling sub-nanogram protein quantities; Optimize protocols for
Plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease required for the initiation of clinical trials; Administer genome-editing therapeutics and other test substances using relevant routes of delivery; Perform animal
Carry out molecular cloning and construct design, including plasmid design, Gibson/Golden Gate assembly, and site-directed mutagenesis; Express proteins using bacterial-, mammalian-cell-based (e.g., E. coli, HEK293), and cell-free protein expression