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Characterise novel cellular models of mitochondrial disease, and use genetic screening approaches to characterise novel nuclear modifiers of disease progression. The focus of your work will be on studying how nuclear and mitochondrial DNA defects lead to
This project aims to test whether targeting ERAP2 can selectively remove pathogenic EBV-infected B cells in MS. Almost everyone with MS carries EBV, and EBV-infected B cells help drive disease. ERAP2 shapes how these B cells present viral peptides to NK
Design and perform genetic and genomics screens to reconstruct maps of functional interactions across the ERN; Design and carry out functional experiments to mechanistically dissect the basis of identified interactions; Identify physiologically relevant