Expert GPCR Cellular Assays

Expert GPCR Cellular Assays

Proteros Biostructures

Munich, Germany

Your mission

• Contribute to multidisciplinary and challenging research projects in the field of drug discovery;
• Provide expert knowledge in GPCR biology, focusing on GPCR/G-protein interactions and ligand pharmacology;
• Independently design, execute, and interpret cellular functional assays for profiling and classifying ligands based on their mode of stimulation;
• Develop and apply fluorescence and luminescence assays with continuous kinetic readout on FLIPR or FDSS workstations;
• Perform ligand screening in HTS mode and ligand profiling experiments;
• Utilize cell culture techniques and select relevant cell lines;
• Ensure compliance with industry standards for screening, profiling, and characterization of ligand–GPCR binding;
• Maintain thorough documentation of work according to internal guidelines and customer requirements using a laboratory management system (LIMS).

Your profile

• Ph.D. in cell biology, pharmacology, biochemistry, or a related field, with a strong focus on membrane protein signaling;
• At least 3 years of experience in a drug discovery environment, covering the process from screening to lead identification;
• Deep understanding of GPCR pharmacology and G-protein interactions;
• Hands-on experience with FLIPR or FDSS workstations;
• Proven expertise in other fluorescence- and luminescence-based GPCR assay technologies, such as TR-FRET, FRET, nanoBRET;
• Strong analytical and problem-solving skills with a high level of accuracy and attention to detail;
• Ability to work independently and in interdisciplinary teams across different projects.

Apply Now