Postdoc Chromatine Biology

Postdoc Chromatine Biology

Leiden University Medical Center

Leiden, Netherlands

At LUMC, as a Postdoctoral Researcher in Chromatin Biology, you contribute to bridging fundamental research with clinical applications. You will focus on investigating the genetic aspects of BAFopathies within a ZonMw-funded project. Your work will involve advanced techniques such as CRISPR and long-read sequencing. You will be part of an international team of dedicated researchers, working together to push the scientific boundaries in this field.

About your role

Within this ZonMw PSIDER Top grant project, your focus will be on understanding dosage sensitivity in BAFopathies—developmental syndromes caused by mutations in the BAF chromatin remodeling complex, among the most common causes of intellectual disability.

Your key responsibilities include:

• Using functional (epi)genomics and CRISPR-based perturbations to investigate molecular defects in patient-specific iPSC models of BAFopathies;
• Generating and analysing next-generation sequencing data;
• Presenting findings at national and international conferences, writing scientific papers, and mentoring junior researchers.

About you

You are an enthusiastic and driven researcher with a completed (or nearly completed) PhD in molecular biology or a related field. You know how to apply your knowledge effectively within an ambitious, international team, where collaboration, autonomy, and clear communication are essential. You thrive in a dynamic research environment and enjoy contributing to collective success.

Furthermore, you have:

• At least one peer-reviewed publication as first author;
• Experience in epigenetics and/or chromatin biology alongside analysis of -omics data (e.g. RNA‑seq, WGBS, ChIP‑seq, ATAC‑seq);
• Proficiency in bioinformatics languages such as R or Python;
• Excellent practical skills in molecular biology, including cell culture, PCR, and western blotting;
• Experience in iPSC culture and differentiation, and preferably CRISPR/Cas9 genome editing.

Apply NowDeadline 14 July