Bioinformatician/Computational Biologist

Bioinformatician/Computational Biologist

IOB - Institute of Molecular and Clinical Ophthalmology Basel

Basel, Switzerland

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated Bioinformatician/Computational Biologist to analyse single cell genomics data, with a focus on the molecular mechanisms of myopia.

Due to myopia’s rising prevalence, it will become the leading cause of blindness worldwide, constituting one of the most significant public health challenges of our time. IOB uses state of the art single cell genomics and epigenomics techniques to advance the mechanistic understanding of myopia at the level of cell types and molecular pathways, and to test new therapies designed to halt or reverse myopia progression. In your role, you will utilise your expertise to collaborate with a multidisciplinary international team and contribute towards major breakthroughs in Human Medicine.

Your responsibilities

• Analyse diverse -omics datasets, including single cell RNA-seq, ATAC-seq and proteomics;
• Create cell type atlases and leverage them to answer biological research questions;
• Support tissue engineering and therapeutic efforts by characterising intra/intercellular signalling pathways;
• Compare diseased cell types to their healthy normal counterparts;
• Organise sequencing data and maintain metadata information;
• Participate in the development of pipelines to automate commonly used workflows;
• Communicate clearly with biologists and bioinformaticians to identify objectives and convey results.

Requirements

• PhD in bioinformatics, computational biology or a related quantitative discipline;
• Minimum 3 years of experience in next-generation sequencing data analysis, preferably including multiomics single cell data;
• Experience in the analysis of spatial transcriptomic data is a plus;
• Competence in Python, R and Unix/Linux is required. Experience with workflow management (Snakemake or Nextflow) and high performance or cloud computing is desirable;
• In-depth knowledge of common sequencing technologies;
• Experience deciphering intra- and intercellular signalling pathways is desirable;
• Excellent written and verbal communication skills in English.

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