Post-doctoral Position - Cell Identity and Gene Regulatory Networks in the Auditory System in Normal and Pathological Contexts
Post-doctoral Position - Cell Identity and Gene Regulatory Networks in the Auditory System in Normal and Pathological Contexts
Institut Pasteur
Paris, France
We are seeking an outstanding, highly motivated advanced scientist in molecular biology and neuroscience for projects on gene regulation and gene regulatory networks with a view to developing innovative treatments for hearing impairments.
Mission
The postdoctoral fellow will work on projects aiming to decipher the molecular mechanisms regulating the expression of genes with key roles in the auditory system. The cell-specific expression of therapeutic genes or the editing of pathogenic variants with viral or non-viral vectors is a major challenge in inner ear gene therapy. The characterization of gene regulatory elements and gene regulatory networks is essential for this purpose.
The candidate will use computational methods to develop and integrate novel transcriptomic analyses (RNA-sequencing, 10X genomics) and epigenetic signatures (DNA methylation, chromatin accessibility, ChIP-sequencing, and Hi-C conformation capture techniques) for the genes involved in hearing and deafness.
Qualifications
- A PhD in molecular biology, genetics, epigenetics or related fields is required
- Two years of postdoctoral experience in these scientific fields is strongly preferred
- Expertise in the characterization of regulatory elements controlling gene expression is highly valued
- Experience in techniques mentioned above
- Knowledge of the auditory system will be appreciated
- Experimental development and troubleshooting are expected as well as independently planning experiments. Ability to keep accurate records and excellent organizational skills are essential. We are looking for a creative, highly motivated, involved, curious, friendly and responsible scientist.
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