Scientist II Bioreactor Process Design

Scientist II Bioreactor Process Design

Evotec

Toulouse, France

General Summary:

Just-Evotec Biologics is looking for Scientist II of Bioreactor Process Design to join a fast-paced, collaborative, and multidisciplinary team working on upstream process development (perfusion and intensified fed-batch) projects. In this role, you will participate in further developing and refining Just’s next-generation continuous bioprocessing platform, which we are currently running in our Seattle and Redmond manufacturing facilities at 500L and 1000L scale. Just-Evotec employees are driven by our mission: to expand access to therapeutics by substantially driving down the cost of goods through process technology development. This role is well-positioned to have a substantial impact on patients and the biotechnology industry.

This position will be part of a team to perform upstream process development for early and late-stage processes and will include process development, optimisation, characterization, and technology transfer for intensified, continuous processes. The successful candidate will be detail-oriented, self-motivated, efficient, curious, and work well in a team environment. Strong written and verbal communication skills, including the ability to communicate effectively over teleconferences and web-based meetings, are necessary.

Missions and responsibilities:

• Driving all aspects of Upstream process development, characterization, and technology transfer to cGMP manufacturing for hybrid and continuous processes;
• Serving as an internal technical resource for cGMP manufacturing and Process Design;
• Clearly and effectively communicating scientific information, experimental plans, and data to internal project teams, senior management, and technology development collaborators;
• Independently designing, executing, and analyzing statistically designed experiments (DOE);
• Authoring work instructions, reports, and slides which summarize, organize, and interpret experiment results with review by appropriate team members;
• Responsible for bench-scale bioreactor operations including run preparation, bioreactor assembly, autoclave, inoculation, daily sampling and analytics, troubleshooting, cleaning, and maintenance;
• Driving technology development for process intensification and continuous manufacturing to reduce manufacturing costs and footprint through improvements in culture productivity, control of product quality, and data management;
• Responsible for equipment calibrations and Media preparations in the Lab;
• Ensure accurate and complete documentation of lab activities and write appropriate technical reports for successful regulatory submission;
• Ensure the upstream development (USP) labs and equipment is maintained under optimal working conditions and assume responsibility for specific instruments;
• Contribute to investigations (e.g., deviations) as required to help identify the root cause and propose and implement appropriate corrective actions;
• Author, amend and review operating documents, such as WI, SOPs, guidelines, and data records. Willing to take on additional activities;
• Documenting best practices and technical results in ELNs, SOPs, summary reports, etc.;
• Working with vendors and manufacturers;
• Availability to work occasionally on weekends and evenings is required. (5-day work week/2 consecutive days off).

Knowledge, skills and abilities:

• Excellent attention to detail, focused when completing technical tasks;
• Strong writing skills and efficient at documentation;
• Excellent experimental design and analysis skills;
• Able to stay organized in complex situations, keep track of multiple tasks and data;
• Enthusiastic problem-solver;
• Experience with Microsoft Office apps (Word, PowerPoint, Excel);
• Experience with cell culture operations, filtration techniques, automation, analysing data using statistical tools.

Experience and education:

• Master’s degree in engineering, Biochemistry, Biotechnology or related field with 7+ years of experience or PhD with 3+ years of experience in Biosimilars for mammalian derived purification process;
• Proficiency in both verbal and written English is essential.

Other information:

• Desire to work in a fast, collaborative, and team-oriented environment.

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