Structural Bioinformatics Lead Scientist

Structural Bioinformatics Lead Scientist

Lonza

Cambridge, United Kingdom

Key responsibilities:

• The successful candidate will work on multiple customer projects focusing on in silico assessments and providing computational design for Antibody based & recombinant protein therapeutics.
• You will utilise our proprietary platforms for antibody humanisation and deimmunisation, immunogenicity (Epibase®) and manufacturability risk assessments to improve the develop-ability of potential bio-therapeutics of customers ranging from small biotech to big pharma.
• Additionally, you will contribute to the development of innovative technologies to support companies in their R&D programs and optimize proteins for the manufacturing processes.

Key requirements:

• PhD or equivalent experience in Computational Chemistry, Structural Biology, Physics or Structural Bioinformatics preferably with proven experience.
• Highly experienced in protein structural analysis with emphasis on homology modeling and protein structure-based design. Strong understanding of molecular interactions is essential.
• Experienced working in Linux environment and scripting (knowledge of Python is essential).
• Experience in designing/developing ADCs would be an advantage.
• Ability to generate high quality reports and promote effective communication with the customer.
• Advanced analytical and critical problem-solving skills, combined with scientific creativity.
• Interest in continuous improvements of processes by integrating innovative solutions.
• Ability to work as a team member, as well as independently with minimal direction.
• Fluency in written and oral English, and strong, written, oral communication skills.

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