Senior Scientific Researcher in Single-Molecule Biophysics
Senior Scientific Researcher in Single-Molecule Biophysics
University of Oxford - Department of Physics
Oxford, United Kingdom
We are looking to hire an outstanding senior scientific staff member to support our group’s research, which focuses on studying DNA and chromatin replication at the single-molecule level. You will form part of the research team core and support the wider group by leading outstanding research and development in single-molecule biophysics.
About the project
In this project, you will design and implement novel forms of biophysical instrumentation (e.g. advanced optical tweezers and magnetic tweezers, single-molecule fluorescence, novel single-molecule approaches to DNA sequencing, integration with cryo-EM) with the goal of maximizing their contributions to the understanding of DNA replication and/or chromatin organization. You will propose and/or implement technical advances on single-molecule instruments and use them together with graduate students and postdocs to acquire data on DNA replication and/or chromatin organization. An aptitude in instrumentation development and quantitative biophysics, a willingness to acquire relevant knowledge into the photophysics of fluorescent labels, and an interest in guiding, coaching, and training graduate students and postdocs in their scientific and technical development, are essential. The overall goal is to provide novel and sound single-molecule biophysical insights into DNA replication and/or chromatin organization to advance these exciting fields.
Requirements
For this innovative, interdisciplinary project, we are looking a (bio)physicist, with:
- A successfully completed Ph.D. degree in biophysics or optical physics;
- Practical experience and scientific maturity in the above areas;
- Strong aptitude and interest in biophysical instrumentation and microscopy, and willingness to acquire related knowledge e.g. photophysics;
- Professional experience with force spectroscopy (e.g. optical tweezers, magnetic tweezers, or atomic force microscopy) or single-molecule fluorescence methodologies;
- Strong skills in hardware-software interfacing and demonstrable ability to interface and collaborate with experts in programming;
- An independent, well-organized, and reliable work style;
- Track record of obtaining scientific funding;
- Leadership ability to guide, coach, and train graduate students and postdocs in the context of an interdisciplinary team;
- Excellent interpersonal communication skills and a strong interest in the broader field of biophysics that will contribute to the interactive lab culture.
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