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Work on a project focused on understanding regulators of T-cell responses in the tumor microenvironment in prostate cancer to develop novel immunotherapeutic strategies. Methods will include processing of human tissues, cell culture, advanced flow
We are interested in mechanisms of tumor initiation and resistance, with an emphasis on tissue long lived cells such as stromal cells, and their crosstalk with tumor cells, immune cells and the vasculature. We perform mostly in vivo studies combining
This project aims to further understand the reprogramming of cells exposed to early and chronic hypoxia in multiple experimental models, with a particular focus on CRISPR and single cell sequencing. The project will involve perturbation experiments in