Scientist I Mass Spectrometry

Scientist I Mass Spectrometry

Evotec

Toulouse, France

Just Evotec Biologics EU is seeking a motivated Scientist, who desires a significant opportunity to improve worldwide access to biotherapeutics. The new scientist will join a fast-paced, collaborative, and multidisciplinary team. As a key member of the Mass Spectrometry group, you will possess skills in LC-MS/MS method development, mAbs and biosimilar characterization.

We are seeking a highly motivated Scientist I for laboratory work. The successful candidate will contribute to the development of regulatory-ready bioanalytical methods for characterization of monoclonal antibodies and antibody-drug conjugates (ADCs), using liquid chromatography-mass spectrometry (LC-MS). The ideal candidate has strong written and verbal communications skills, excellent organizational skills and works well in teams.

Responsibilities:

• Develop and perform large molecule analytical and characterization assays under the supervision of senior scientists, including identity testing by intact mass and/or subunit analysis, glycan profiling, primary structure and PTM analysis by peptide mapping;
• Perform routine sample preparation, injections, acquire LC-MS data, analyze data, draft report and document experiment in ELN to support process development;
• Perform routine maintenance of HPLC and MS systems, prepare mobile phases, execute calibration and cleaning procedures, coordinate regular preventative maintenance troubleshooting under the supervision of senior scientists;
• Author technical documents including analytical methods, standard operating procedures, qualification reports, and technical reports;
• Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals;
• Track and document assay performance;
• Present scientific data to analytical department and cross-functional teams.

Requirements:

• BSc +10 years’ experience, or MSc 0-5 years of experience in Chemistry, Biochemistry, or related field;
• Experience in analytical method development for identification and quantification using mass spectrometry;
• Good knowledge and demonstrated ability working with large molecule separation methods including reversed-phase HPLC, SEC or HILIC;
• Solid understanding of mass spectrometry operating principles, including ionization, ion transfer, gas-phase fragmentation, and mass analyzers is a plus.

Preferred qualifications:

• Expertise with Orbitrap MS and Q-ToF MS (Exploris 240 or XevoG3);
• Experience with Byos software;
• Highly organized with a strong attention to detail, clarity, accuracy, and conciseness;
• Good written and verbal French & English communication skills;
• Desire to work in a fast, collaborative, team-oriented environment.

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