Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 2574
Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 2574
MRC Laboratory of Molecular Biology
Cambridge, United Kingdom
The position is for a Postdoctoral Scientist with expertise working with mouse models of degenerative diseases.
You will join Dr Anne Bertolotti’s pioneering research programme, which focuses on innovative approaches to rescue cells from protein misfolding, a condition at the origin of many human diseases, including neurodegenerative diseases. One of such approaches consists in targeting eIF2a phosphatases and kinases to boost protein quality control capacity (see Tsaytler et al., 2011, Science, 332, 91-4; and Das et al., 2015, Science, 348, 239-242, Carrara, M., Sigurdardottir, A., & Bertolotti, A. (2017). Nat Struct Mol Biol, 24(9), 708–716). Krzyzosiak, A., Sigurdardottir, A. et al., A. (2018). Cell, 174(5), 1216–1228.e19; Schneider K. et al., (2020), Sep 15;32(11):108154, Cell Reports; 1.Pitera, A. P., et al,. Embo J 41, e109985 (2022); Szaruga M. et al., Nat Commun. 2023; Rai S, et al. J Cell Biol. 2024.).
You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animal models of neurodegenerative diseases. The team also has an excellent record of innovative basic research leading to applications in medicine.
You will be ambitious, creative and fearless, able to invent new approaches to explore the unknown. You will have a PhD in neuroscience or molecular biology/genetics or pharmacology or due to complete doctoral studies within 6 months of applying. Relevant experience working with mouse models is required, and this must be best attested by at least one impactful publication. Interests in neurological diseases is desirable. It is also essential to have publications in this area.
You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown.
This is a two-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.
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