Post-doctoral Position on the Characterization of Novel Enzymes Involved in Methanogenesis
Post-doctoral Position on the Characterization of Novel Enzymes Involved in Methanogenesis
Institut Pasteur
Paris, France
A two-year post-doctoral position funded by a project grant of the ANR (The French National Research Agency), is available from January 2025 in the laboratory “Evolutionary Biology of the Microbial Cell” headed by Simonetta Gribaldo, Professor at Institut Pasteur, Paris, under the supervision of Guillaume Borrel, head of the group “Evolution and Metabolism of Archaea”.
Offer Description
Methanogenesis is an archaeal-specific metabolism of key relevance in the global anaerobic degradation of organic matter and biogas production. This metabolism could have been active as early as 3.46 Gy ago and had a direct impact on the evolution of the Earth’s climate system, with an important implication in current global changes. Methanogens are present in all types of anaerobic environments such as extreme environments, wetland soils and the gastrointestinal tract of animals (including humans). In the past decade, large-scale reconstruction of genomes from metagenomes in a wide range of environments has led to a great expansion of our knowledge of methanogen diversity. Building up on this diversity, we identify uncharacterized enzymes associated to all methanogens or to specific pathways. We now aim at validating the inferred function of these enzymes through different molecular biology, biochemistry and microbiology approaches.
The candidate
Curious, highly motivated candidates must hold a PhD in biology and should have an expertise in biochemistry, genetics and microbiology. Knowledge in multi-omics would be appreciated. The candidates must demonstrate excellent autonomy, communication, and collaboration skills, and must speak English with our collaborators.
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