Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 2548

Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 2548

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

The position is for a Postdoctoral Scientist with expertise on kinases, protein biochemistry and enzymology. You will be responsible for expressing, purifying kinases and analyze the mechanism of action of newly discovered small molecule activators using biochemical, enzymatic and cell-based assays.

Dr Anne Bertolotti’s pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al,. Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024). The small molecules discovered by the lab are currently tested in clinical trials for neurodegenerative diseases. You will provide fundamental mechanistic insights on these important enzymes and expand on the next generation of small-molecule activating kinases.

You will be ambitious, creative and fearless, able to invent new approaches to explore the unknown. You will have a PhD in biochemistry or due to complete doctoral studies within 6 months of applying. Relevant experience is required, and this must be best attested by at least one impactful and original publication. Interests in kinases and signaling is essential.

You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown.

This is a three-year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.

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