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The project involves advanced techniques such as ex vivo calcium imaging of mouse and human urothelium, X-ray videocystometry in awake mice, and optogenetic modulation of urothelial cells. The candidate will design and conduct experiments exploring
This work is focused on the specific targeting of clinical mutations that cause dominant inherited Alzheimer’s disease using an unique antisense strategy (ASO). We will couple those ASO to our proprietary blood-brain shuttles to improve brain exposure,