Postdoctal Research Position: Tumor Cell Biology - T Cell Acute Lymphoblastic Leukemia (T-ALL)
EPFL - Swiss Federal Institute of Technology Lausanne
Lausanne, Switzerland
You will extend a previous research endeavor to unravel the single or combined role of two crucial transcription factors and/or chromatin remodelers in established T-ALL disease settings. A major interest is to evaluate how specific transcription factors are involved in shaping the pre-leukemic state and subsequently maintenance of Notch1-driven T-ALL by assessing the chromatin structure of transformed leukemic cells. Using epigenetic analysis tools downstream after extracting stage-specific leukemic cells, you will be able to perform functional studies including but not limited to proliferation and cell cycle analysis, apoptosis, RNA- and ATAC-seq.
Main duties and responsibilities
Driving force in conducting the research, develop the experimental designs and work in collaboration with the hematopoiesis team in the lab and bioinformaticians.
- Responsible for experimental design, conducting the experiment, data acquisition and critical evaluation;
- Reporting of research results in lab meetings, seminars, conferences and writing scientific articles.
Profile
The ideal candidate should have:
- PhD degree in cell biology with a solid background in cancer biology, hematopoiesis and/or genetics required;
- Experience in designing and handling experimental animal models (mouse) of blood borne cancers;
- Experience in multiparameter flow cytometry;
- Experience in tissue culture, cloning techniques and epigenetic techniques;
- Experience in Scientific Computing Software (Python, Linux) will be a plus;
- LTK1 module or equivalent required;
- Working knowledge of laboratory information system (LIMS), electronic laboratory notebook (ELN) and statistical analysis are beneficial;
- Language skills - good knowledge of English (verbal and writing) a prerequisite;
- Good communication and organizational skills;
- Capacity to collaborate to achieve common objectives;
- Good management and interpersonal skills.
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