Post-doctoral Position: Exploring Host-microbe Interaction at the Nasal Passage
Post-doctoral Position: Exploring Host-microbe Interaction at the Nasal Passage
Institut Pasteur
Paris, France
The work…
With Dr. Michael Connor, we will study the interface of nasal epithelial cells with both commensal and pathogenic bacteria. Our goal is to understand how nasal commensal bacteria (Corynebacterium accolens) function as a microbial barrier to pathogen (Streptococcus pneumoniae & Moraxella catarrhalis) colonization and respiratory disease progression.
Our topics of investigation aim to describe:
- How commensal respiratory bacteria establish their niche and persistently colonize the nasal space;
- How commensal bacteria function as a microbial barrier to disease through their ability to shape innate immunity via host cell biology and potential antimicrobials;
- How pathogens displace or overwrite commensal-nasal epithelial homeostasis in order to establish themselves.
The candidate?
You are a motivated and curiosity driven scientist that is eager to learn how host-bacterial interaction shapes molecular processes, cellular biology/signaling/sensing and innate immunity.
You hold a PhD with multidisciplinary training in the field of microbial pathogenesis. This project will draw upon and further develop your training across bacteriology, cell biology, innate immunology and molecular genetics.
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