Postdoc - Knipscheer Group
Postdoc - Knipscheer Group
Hubrecht Institute
Utrecht, Netherlands
Project description:
Maintaining the integrity of our genome is crucial to prevent genetic diseases such as cancer. We use a powerful biochemical system, the Xenopus egg extract system, that recapitulates DNA replication and repair using a physiological mechanism. This allows us to dissect the mechanisms of complex genome maintenance pathways and study the functions of novel and known proteins. We combine this system with novel sequencing-based methods to examine the dynamic behaviour of key proteins during these processes, to identify rare DNA repair intermediates, and to study mutagenesis. In this project we will develop long-read sequencing methods and combine these with our biochemical assays to gain novel insights in DNA repair processes and the role of chromatin. We provide a highly collaborative and ambitious environment, with access to top-class facilities.
Requirements:
We are looking for a highly motivated and independent scientist, with a collaborative mindset who enjoys working in an international team. A background in protein biochemistry or bioinformatics is required. The candidate should have an PhD degree and excellent communication skills in English.
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