Post-doctoral Researcher on HIV Latency Regulation (Genomics Specialist)
Post-doctoral Researcher on HIV Latency Regulation (Genomics Specialist)
Institut Cochin
Paris, France
Research project
Almost 40 million people worldwide live with HIV, and a major obstacle to its eradication is the virus's persistence in a latent state within reservoir cells. Our research group at Institut Cochin specializes in understanding how HIV-1 latency is established and maintained in CD4+ infected cells. We have recently identified several pathways involving host cell epigenetic and RNA metabolism factors that lead to HIV-1 silencing at both the transcriptional and post-transcriptional levels.
We are seeking a highly motivated Postdoctoral Fellow to characterize one of these critical pathways at the RNA/Chromatin interface, which has been shown to be essential for HIV-1 silencing.
Main Activities
- Conduct and carry out research activities on both intellectual and experimental levels.
Job specification(s) and environment
The Post-Doctoral position will take place in the recently established “RNA metabolism and HIV latency” group led by Roy Matkovic and composed of a PhD Student and the PI. This group is part of the Retrovirus, Infection and Latency team directed by Florence Margottin-Goguet and Claudine Pique. The project that the postdoctoral researcher will lead is funded.
Expertise
- Solid knowledge in Biochemistry, Epigenetics and Transcription regulation, knowledge on HIV replication cycle is a plus.
Know-how
- Biochemistry/Cellular and Molecular Biology/Bioinformatics: Co-immunoprecipitations, CUT&RUN/Tag, RNA-seq, ATAC-seq and Bioinformatic analyses.
Ability
- Ability to share expertise and results;
- Ability to propose new ideas (intellectual/experimental);
- Competent in presenting work to peers (national and international conferences). Proficiency in English, French is optional.
Experience(s) required
- Proven experience in conducting and analysing advanced techniques in gene expression regulation and epigenetics (PhD).
Diploma level and training
- PhD thesis is required.
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