Post-Doctoral Research in Host-Virus Co-existence and HIV Infection Dynamics

Post-Doctoral Research in Host-Virus Co-existence and HIV Infection Dynamics

Institut Pasteur

Paris, France

We are seeking a bright, curious, and flexible scientist to join our research team at the Institut Pasteur. Our study focuses on the intricate dynamics of the human immunodeficiency virus (HIV) during the early stages of infection, particularly within the host cell nuclei. Despite years of research and established dogmas, recent studies have unveiled new aspects of these early steps, highlighting the complexity of HIV's journey inside the host.

Aspects on spatial organization of cells in organs and how the mechanodynamics stress can influence the nuclear viral journey is the aim of this study. The virus to enter the nucleus encounter the first barrier constitute by the nuclear pore complex that can be linked to nuclear membraneless organelles, all these steps should occur under the shadow from the innate immunity that is the first immunity defence against viruses.

Key Aspects of the Role:

• Our group combines molecular and cell biology, virology, and quantitative microscopy techniques, such as single-particle tracking of viral genomes;
• This project will leverage unique live cell tools we have developed to track the virus as it reverse transcribes its genome directly into the host nucleus;
• The candidate will have the opportunity to work with several cutting-edge platforms on campus, with a collaborative interdisciplinary team, and under the guidance of an enthusiastic and passionate mentor.

Requirements:

• A Ph.D. degree in virology, cell biology, biophysics, or related fields;
• Enthusiasm, motivation, and passion for uncovering new insights into viral-host interactions;
• Demonstrated ability to conduct independent research.

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France      Biology      Biomedical and Physiology      Microbiology      Not for Profit      Postdoc      Institut Pasteur