Post Doc - Selective Vulnerability in Alzheimer's Disease

Post Doc - Selective Vulnerability in Alzheimer's Disease

VIB

Leuven, Belgium

Your job

Do you want to help find out what is really going on in Alzheimer's disease? Why does the disease sweep through the brain in such a determined manner? Why do amyloid aggregates form in certain brain regions and not others? Why are some brain regions devastated and others spared?

In our previous work, we have identified a new mode of amyloid interactions based on local sequence similarity to aggregation-prone regions and the National Institute on Aging has just granted us a 5-year project to investigate the interaction of amyloid-beta and tau with other brain region-specific proteins.

The project entails:

  • a genome-wide computational screen for specific (heterotypic) interactions between the aggregation-prone regions of amyloid-forming proteins and the background proteome;
  • testing the candidate proteins in cellular models and then in mice;
  • biophysical analyses to discern the exact mechanism by which heterotypic interactions change amyloid formation.

We’re looking for a postdoc to join a growing team to take this project to fruition.

Your profile

  • A Ph.D. in a topic related to protein aggregation/protein biophysics;
  • A keen interest in protein aggregation and its role in disease;
  • Expertise in biophysical or biochemical methods to study protein aggregation;
  • A high affinity for bioinformatics;
  • A solid publication record;
  • Highly motivated, enthusiastic, critical, and creative;
  • Excellent written and oral communication skills;
  • Can supervise doctoral/master's students;
  • Can work in a multidisciplinary and multicultural team;
  • Experience with mammalian cell culture or high-content screening is a plus.

Apply Now

Don't forget to mention EuroScienceJobs when applying.

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© EuroJobsites 2022

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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