Metabolites mediate essential cellular responses to environmental change, which ensures our survival. Vital gene programs are responsive to the intake of dietary glucose, fructose and ethanol. They convert excess carbohydrates into fat, which promotes the metabolic syndrome. But how sugars actually promote specific changes in gene transcription is far from clear.
Our team has a world-leading record in the discovery of interactions between gene regulatory factors and cellular metabolites and to translate these discoveries toward novel therapies. We have now identified and validated a druggable metabolite-binding pocket in a vital factor. We will apply our know-how to develop small molecules that will therapeutically switch carbohydrate-driven gene programs.
We seek an enthusiastic and committed postdoc for an exciting frontline project at the interface of biomedical sciences, physiology and drug discovery. The fellow will investigate at the biochemical, cell biological, structural, chemical and small molecule level how the activity of our carbohydrate-regulated factor can be switched by the identified and validated small molecule probes and chemical leads. Our new knowledge and expertise will allow us to address one of the biggest challenges in drug discovery, the targeting of transcription factors via small molecules, for the benefit of patients.
Candidates should be motivated, curious, project-, task- and team-oriented, communicate well and enjoy working together on pioneering projects at the forefront of biomolecular recognition. Ideally, you have a background in oncology, gene expression, metabolism, drug discovery or small-molecule chemistry.
The successful candidate will collaborate within our team and across our outstanding academic and biotech campus. The salary is based on the public scale TV-L E13. The employment is planned for a period of up to 3 years and can be extended. Opportunities exist to spin-off the project into an entrepreneur-led start-up company pending the achievement of project milestones.
Please send your CV, motivation letter and the names of three referees in a single PDF file by email to: firstname.lastname@example.org. We look forward to your expression of interest.