Postdoc in Structural Biology - Vannini Group

HT - Human Technopole

Postdoc in Structural Biology - Vannini Group

HT - Human Technopole

Milan, Italy

Job description


Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centres: Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science. The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

The Human Technopole Foundation is looking for a Postdoc to work in the Structural Biology Research Centre in the laboratory of Prof. Alessandro Vannini.

The Vannini Group combines cryo-electron microscopy (both SPA and cryo-ET), X-ray crystallography, mass spectrometry, single molecule measurements and various biophysical techniques to elucidate the role of multi-subunit macromolecular machineries in genome function and organization. In particular, we are interested in understanding at the molecular level how non-coding gene transcription machineries, auxiliary transcription factors, chromatin remodellers, SMC complexes and transposable elements affect gene expression and genome structure.

The HT Centre of Structural Biology has top-notch managed facilities for Cryo-EM (Titan Krios, 1 Glacios, 1 Aquilos2, 1 Spectra, 1 Talos 120), cryo-CLEM, Light imaging, XL- and native mass -pectrometry and support units for Biophysics (mass photometry, SEC-MALLS, ITC, x-ray crystallography etc.), Biomass production (E,coli, yeast, insect cells, suspension mammalian cells with fermenters up to 150 litres) and a dedicated managed platform for single molecule experiments on optical tweezers (Lumicks C-trap and M-trap).

We are looking for highly motivated and creative individuals with a strong interest in structural and functional characterization of large multi-subunit complexes, using integrative approaches. Previous expertise in structural biology or, in alternative, RNA biochemistry is essential. We encourage international candidates to apply and will support applications to external Postdoctoral fellowship schemes (EMBO, Marie Curie, HPSF, etc.).

Key tasks and responsibilities:

  • Investigating the role of transcription factors, architectural complexes and chromatin remodellers into high order chromatin structure and function, integrating structural biology data (cryo-EM, CLEM, XL-MS) with light imaging and functional in vivo data;
  • Present scientific work at seminars within the Human Technopole and at international meetings;
  • Generate reliable data for publication and record all data and results in specified forms (paper and electronic);
  • Contribute to the writing of project related scientific papers;
  • Assist in the training of PhD students and contribute to the smooth running of the lab.

Job requirements

Mandatory requirements:

  • A PhD in fields related to Biology, Biophysics, Physics, or similar;
  • Previous experience in biochemistry and/or Structural Biology;
  • Fluency in English.

Additional requirements:

  • Experience in cryo-EM is a plus;
  • Experience in genome editing is a plus;
  • Ability to write research and review articles and prepare and present data and results to a scientific audience;
  • Ability to work independently as well as in a team;
  • Ability to work in a multi-cultural, multi-ethnic environment with sensitivity and respect for diversity;
  • Ability to manage competing priorities in a fast-paced environment and to work independently;
  • Ability to build trust through operating with transparency and creating an open and positive environment.

Application Instructions

Please apply by sending a CV and a up to 2 pages of detailed motivation letter in English only through the dedicated area below (Apply now) and the name and contact details of at least 2 potential referees.

Additional Information:

HT offers a highly collaborative, international culture to foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows and core facilities.

HT is an inclusive employer that fosters diversity and engages systematically to ensure that equal employment opportunities are provided without regard to age, race, creed, religion, sex, disability, medical condition, sexual orientation, gender identity or expression, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws. HT offers attractive conditions and benefits appropriate to a leading, internationally competitive, research organisation that promotes a collegial and open atmosphere.

Please note that researchers coming to Italy for the first time, or returning after residing abroad, may benefit from very attractive income tax reductions.

General enquires concerning the role should be sent to Prof. Alessandro Vannini ( Applications should not be sent to this address.

Number of positions offered: 1
Contract offered: CCNL Chimico Farmaceutico, Employee level, contract duration fixed-term 4 years.

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Don't forget to mention EuroScienceJobs when applying.

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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