Postdoctoral Position - Exploring the Stress Response Pathways Linked to Neurodegeneration: Contribution from Aminoacyl-trna Synthetases

Postdoctoral Position - Exploring the Stress Response Pathways Linked to Neurodegeneration: Contribution from Aminoacyl-trna Synthetases

University of Antwerp

Antwerp, Belgium

Job description

We are looking for an enthusiastic postdoctoral researcher to explore the stress response pathways specifically regulated by the nuclear translocation of TyrRS and the connection to peripheral neuropathies. You will benefit from our prior knowledge and will test specific hypotheses in well-characterized Drosophila DI-CMTC models using genetic and behavioral analyses, immunohistochemistry, biochemistry and molecular biology, fluorescence and confocal microscopy. The molecular findings established for TyrRS will be tested in fly models for other CMT-causing aaRS to identify a potential shared disease pathway. You will further have the opportunity to validate the findings in available cellular DI-CMTC models, including patient-derived iPSC-motor neurons. You will be embedded in an international team of scientists working on complementary topics and model systems, allowing for helpful discussions and fruitful collaborations. At the same time, you will be expected to work independently and drive your own research project. You will supervise Master’s and potentially also Ph.D. students.

Profile

Essential

  • Ph.D. degree in (neuro)biology or related disciplines.
  • Strong background in Drosophila genetics and (neuro)biology.
  • At least one accepted first-author publication in an international peer-reviewed journal.
  • Capability to independently plan, execute and troubleshoot your daily work, and propose relevant research directions.
  • Motivation, flexibility and team spirit.
  • Excellent verbal and written English communication skills.

Desirable but not required

  • Background knowledge on the cellular mechanisms of stress response and/or neurodegeneration.
  • Experience with cell culture and iPSC technology.
  • Experience with NMJ morphological and electrophysiological analysis.

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© EuroJobsites 2021

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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