The Faculty of Pharmaceutical, Biomedical and Veterinary Sciences at the University of Antwerp is seeking to fill a full-time (100%) vacancies in the Department of Biomedical Sciences for a postdoctoral researcher in the area of ferroptosis.
You will be working in the Vanden Berghe lab on the introduction of ferroptosis inhibitors into the clinical practice of organ transplantation.
Background research topic: Oxidative stress can kill cells in an iron-dependent way. This type of cell injury is known as ferroptosis. Currently, the success of organ transplantation is hampered by a shortage of suitable organ grafts and the adverse effects of ischemia reperfusion injury (IRI). IRI, or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue after a period of lack of oxygen supply. Inflammation and cell death in the transplanted organ, caused by the activation of the immune system, leads to primary graft dysfunction. We will use a novel ferroptosis inhibitor to block ischemia reperfusion injury during preservation of the organ grafts. This project is supported by Research Foundation Flanders (FWO) and is a high-level collaborative project with the Medicinal Chemistry lab of the UAntwerp and a team of transplant surgeons of the KULeuven.
Research topic for this postdoc position: 1) determine efficacy of candidate lead ferroptosis inhibitors in ferroptosis-driven organ injury and in rodent IRI models and 2) identification of novel ferroptosis inhibitors
Next to experimental research, you will write project reports for your supervisor on a regular basis, write scientific papers and support grant writing.
An appointment as a postdoctoral researcher for a period of one year, with a possibility of renewal for an additional 2 years.
The date of appointment: October 1st, 2021, or soon after that.