A post-doctoral position funded by the FRM (French Foundation for the medical research) is available in the group of László Tora at the Institute for Genetics, Molecular and Cellular Biology (IGBMC) in Strasbourg (France). Our lab's interest is focused on protein complexes involved in transcription initiation and activation as well as in chromatin organization. We have uncovered a new oocyte-specific basal transcription machinery, since during oocyte growth the TATA-binding protein (TBP), a canonical subunit of the TFIID general transcription factor, is replaced by the vertebrate-specific TBP-like protein TBPL2. Our main goals are the functional and structural characterization of the specific TBPL2-containing transcriptional machinery and the understanding of its biological significance during mammalian oocyte growth.
We are looking for a highly motivated, interactive and experienced candidate with strong expertise in molecular biology and mouse molecular genetics. Additional experience in genomics, transcriptomics, and/or genome-wide data analyses will be valued. In their motivation letters the candidates should describe why they want to join the project and how they think to contribute to the success of the on-going projects.