Lab Manager - Functional Genomics Programme

HT - Human Technopole

Lab Manager - Functional Genomics Programme

HT - Human Technopole

Milan, Italy

Job description

APPLICATION CLOSING DATE: 28 May 2021

The Human Technopole is looking for a Lab Manager for the Centre for Genomics – Functional Programme.

The successful candidate will be responsible for coordinating and maintaining the wet lab infrastructure of the centre. This includes sample handling, next-generation sequencing, single-cell profiling, molecular biology, nucleic acids manipulations and tissue culture. Specifically, the Lab Manager will be part of a group of specialised technical posts that will perform cell and tissue collection, flow cytometry and cell sorting, nucleic acid preparation, multi-omic profiling, single-cell sequencing, genome editing and potentially imaging data generation (histopathology and immunohistochemistry) within the Centre. Besides lab management duties, the candidate will also be directly involved in the generation of sequencing data from various types of libraries from human and model systems.

The group will rely on bioinformatics support from core posts and will work closely with the computational members of the centre, as well as other centres of HT. Data generation will be supported by the Genomics Core Facility of HT, with which the Centre for Genomics will interact on a day-to-day basis.

A key mission of the role will be to enable members of the centre for make use of its experimental infrastructure. The lab manager will also be expected to ensure that the experimental work within the centre is state-of-the-art and will contribute to the development of new protocols and the rapid standardization/implementation of new technologies. They will also be involved in the recruitment, training and mentoring of staff.

The successful candidate will report directly to the Head of the Centre for Genomics – Functional Programme.

Key Tasks And Responsibilities

  • Coordinate and maintain a molecular biology laboratory to process samples for various multi-omic profiling techniques;
  • Interact with a team of technical posts within the centre that are part of the experimental infrastructure;
  • Generate next-generation sequencing libraries from patient samples and model systems;
  • Work with the Genomics Core Facility for sample sequencing;
  • Be responsible for implementing priorities and resource planning for the centre;
  • Supervise sample preparation, data collection, evaluation and quality control;
  • Ensure the genomics data generation is world-class;
  • Coordinate sample tracking and storage;
  • Be responsible for Health and Safety in the lab;
  • Keep track of lab stocks and order consumables at need;
  • Cooperate with other groups to implement or develop novel technologies;
  • Manage funding and access charges with periodic review to ensure sustainability and competitiveness;
  • Constantly promote protocols optimisation to maximise cost-effectiveness;
  • Supervise scaling-up protocols for high-throughput studies;
  • Closely follow technological developments that could benefit the centre;
  • Interact with the manufacturers and engineers of the relevant equipment;
  • Organise introductions and assistance for new users of the unit;
  • Help select, lead and mentor junior staff;
  • Prepare for centre reviews by external experts;
  • Participate actively in the overall development of HT core facilities;
  • Build effective links and collaborations within HT;
  • Develop links with other national and international genomics facilities;
  • Support third-party fundraising where possible.

Job requirements

  • +5 years of hands-on experience in the use of high-throughput sequencing technologies, single-cell sequencing and/or long-read technologies, and/or other genomics technologies;
  • PhD or equivalent qualification in a relevant subject, e.g. molecular biology, genetics, biochemistry or a related field of science;
  • +3 years’ experience in a managerial role in a laboratory or facility;
  • Documented experience with setting up workflows and robust standard operating procedures for quality assurance;
  • Experience in sample preparation and tracking, specifically human tissues;
  • Excellent laboratory skills and trouble-shooting;
  • Ability to interact effectively with other teams and work synergistically to drive projects forward;
  • Highly organised and meticulous;
  • Fluency in English – HT is an international research institute;
  • Proven leadership, communication, team building and problem-solving skills.

Application Instructions

Please Apply Online By Sending:

  1. a CV in English;
  2. a motivation letter in English;
  3. names and contacts of 2 referees.

Only for general enquires concerning the role, please contact: piero@humantechnopole1.recruitee.com (this email address should not be used to send applications).

Additional Information

HT offers a highly collaborative, international culture to foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows and core facilities.

HT is an inclusive employer that fosters diversity and engages systematically to ensure that equal employment opportunities are provided without regard to age, race, creed, religion, sex, disability, medical condition, sexual orientation, gender identity or expression, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws.

HT offers attractive conditions and benefits appropriate to a leading, internationally competitive, research organisation that promotes a collegial and open atmosphere. The compensation package granted will be internationally competitive and comprise pension scheme, medical and other social benefits and support for relocation and installation. Candidates coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits.

The Human Technopole Foundation is based in Milan.

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