This project will take advantage of exciting preliminary data that needs to be validated and further investigated in available cellular CMT models, including pluripotent stem cells (iPSCs) derived from CMT patients and isogenic controls. The project will entail differentiation of iPSC into motor neurons and their general and actin-tailored characterization. Furthermore, specific pathomechanistic hypotheses will be explored, suggested by our preliminary studies. Next to the iPSC technology, this project will make use of biochemistry, cell and molecular biology, Multi-Electrode Array (MEA) electrophysiology, interactomics, and advanced microscopy techniques. You will be embedded in a team of scientists working on complementary topics and model systems, allowing for helpful discussions and fruitful collaborations. At the same time, you will be expected to work independently and drive your own research project. You will be given the opportunity to supervise and be a (co-)promotor of Master’s students and potentially also Ph.D. students.