Postdoctoral Fellow in Basic Malaria Research

Postdoctoral Fellow in Basic Malaria Research

University of Basel

Basel, Switzerland

We are seeking a postdoctoral scientist to help us investigating how malaria parasites interact with their environment. We aim at understanding the molecular mechanisms intra-erythrocytic parasites employ to sense environmental changes and how this information is translated into cellular responses. The candidate will use the human malaria parasite Plasmodium falciparum to (i) identify and functionally characterize parasite-encoded as well as host cell-derived factors that control environmental sensing and (ii) identify downstream adaptation responses. Our group uses a diverse set of reverse genetics approaches (e.g. CRISPR/Cas9- and DiCre recombinase-mediated gene editing) in conjunction with state-of-the-art techniques for functional analyses (e.g. high content imaging, ChIP- and RNA-Sequencing, phosphoproteomics). The candidate will work on her/his own specific project as well as in close collaboration with other group members.

Your position

  • Generate transgenic P. falciparum parasite lines;
  • Generate transgenic red blood cells via manipulation of erythroid precursors;
  • Identify signalling pathways using phosphoproteomics approaches;
  • Test involvement of candidate factors in parasite environmental sensing using inducible knock-down and knock-out strategies;
  • Functionally analyse candidates using diverse molecular techniques.

Your profile

  • Cell culture (mammalian and ideally P. falciparum or other protozoan parasites);
  • Molecular cloning and transfection;
  • Transcriptomics and (phospho-) proteomics techniques, incl. analysis;
  • Excellent command (speaking and writing) of English;
  • Enthusiasm for studying malaria parasite biology.

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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