We are seeking a Research Associate/Fellow to join a multidisciplinary project funded by EPSRC’s New Horizons Scheme. The overall project aim is to devise a novel workflow for the imaging of drug compounds in brain tissue using complementary in vivo, in vitro and ex vivo approaches. The successful candidate will join highly motivated and well-funded research teams across the Schools of Pharmacy and Medicine. The work is a new collaboration between Rian Griffiths, Peter Harvey, Ruman Rahman and Cameron Alexander.
The aim of this post will be to devise a workflow combining complementary mass spectrometry, magnetic resonance imaging (MRI) and optical imaging approaches for monitoring of a known glioblastoma multiforme (brain cancer) drug compound. An existing drug will be tagged with a MRI active compound synthesised in a wet chemistry lab and characterised via standard synthetic techniques. This will then be used in murine models for in vivo MRI. The successful candidate will be responsible for synthesis, utilising MRI, secondary ion mass spectrometry (ToF-SIMS) imaging and optical microscopy techniques, data processing and data interpretation.
This work will be based within the Division of Advanced Materials and Healthcare Technologies, located with the School of Pharmacy and led by Dr Rian Griffiths. The candidate will be required to undertake research and day-day management of this research project, requiring a high degree of competence in one or more of the research areas listed. An aptitude for critical thinking and a flexible approach to collaborative research is vital.
Candidates should have a PhD thesis submitted or awarded in chemistry, biochemistry, pharmacy, or related discipline together with an interest in analytical approaches and drug delivery.