Postdoctoral Researcher - the Role of Long Non-coding RNAs on the Molecular Circuitry and Metabolic Adaptation of Breast Cancer

Postdoctoral Researcher - the Role of Long Non-coding RNAs on the Molecular Circuitry and Metabolic Adaptation of Breast Cancer

iMM Lisboa - Instituto de Medicina Molecular

Lisboa, Portugal

Work Plan Activities:

Despite improvements in cancer therapies, metastatic solid cancers remain largely incurable. The discovery of ER+ and HER2+ as therapeutic targets in breast cancer (BC) has enabled treatment success with blocking therapies. On the other hand, metastatic triple-negative BC (ER-/PR-/HER2-) is an aggressive subtype of BC marked by poor survival. No therapy exists and therefore patients have an unmet medical need. Finding alternative strategies are a requirement in cancer treatment and patient welfare. Accumulating knowledge indicate a prominent role for long noncoding RNAs (lncRNAs) in cancer cell survival, growth and metastatic potential. LncRNAs are a heterogeneous group of non-coding transcripts that regulate gene expression through diverse mechanisms. Our preliminary results demonstrate that lncRNAs can be manipulated with biomedical applications. These findings have raised the likelihood that lncRNAs represent an unexploited reservoir of potential therapeutic targets for BC.

Profile of Candidate:

Any National, foreign and stateless candidate(s) that hold the following requirements can apply:

  • PhD in biomedical sciences or any related area;
  • Strong experience in cellular and molecular biology, including cloning and transfection;
  • Experience with mammalian cell culture (mandatory);
  • Experience with bioinformatics tools (mandatory);
  • High quality publication track record, with first authorship publications in high quality peer-reviewed scientific journals (highly valued, h-index > 10);
  • Scientific Experience abroad (highly valued);
  • Excellent knowledge of written and spoken English;
  • Good communication and presentation skills.

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© EuroJobsites 2021

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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