Postdoctoral Position - Maiuri Group

Postdoctoral Position - Maiuri Group

IFOM The FIRC Institute of Molecular Oncology Foundation

Milan, Italy

ABOUT THE POSITION

We are looking for a postdoctoral researcher to join the Spatiotemporal organization of the nucleus program at IFOM, Milan, Italy.

Our group studies how cells sense and react to mechano-chemical stimuli coming from the surrounding micro-environment. Particularly, we are interested to investigate how those stimuli impact on the cell nucleus.

ONGOING RESEARCH PROJECTS

Nuclear Volume

Cell and nuclear volumes are related and they constantly grow during the cell cycle. Since alterations of nuclear shape and size are well recognized hallmarks of cancer, we are interested in develop a method to measure the nuclear volume. Such method would allow us to study the nucleus-to-cell volume ratio in homeostasis, investigating not only its variation during the cell cycle but also how it is perturbed upon tumor transformation. Different techniques have been proposed to quantify the cell volume, with a variety of accuracy and sensitivity. However, none of them is able to measure simultaneously cell and nuclear volumes of individual cells in real-time.

The intrinsic shape of the nucleus

While the nuclei of most cells tend to be either round or oval, various diseases are associated with alterations in the shape of the cell nucleus. An abnormal nuclear shape and size is associated with cancer, in fact, it is one of the key diagnostic tools used in identifying malignant cells. Moreover, mutations in genes encoding lamins, one of the major structural components of the nucleoskeleton, are leading to a variety of disorders, including muscular dystrophy, dilated cardiomyopathy and progeria, and show cells with characteristic perturbation of the nuclear shape. Yet, the basic mechanisms linking cell and nuclear shape, and which is the intrinsic shape of the nucleus, are still unclear.

REQUIRED SKILLS

  • PhD or equivalent degree in Biophysics, Engineering, Biological Science or other related fields.
  • Track record of publications in peer-reviewed journals.
  • Proficiency in basic cell biology and imaging.

ADDITIONAL DESIRED SKILLS

A background in microfabrication and/or microfluidics would be appreciated and considered a strong advantage.

Apply Now

Don't forget to mention EuroScienceJobs when applying.

Share this Job

© EuroJobsites 2021

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

Newsletter | Recruit | Advertise | Privacy | Contact Us

© EuroJobsites 2021

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

This website uses cookies to make your experience better. Continued use of this website means you accept our cookie policy.  Accept Cookies