Postdoctoral Scientist in Computer-aided, Structure Based Drug Discovery (f/m/x)

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Postdoctoral Scientist in Computer-aided, Structure Based Drug Discovery (f/m/x)

Helmholtz Zentrum München

Neuherberg, Germany

Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

The Structure-based Drug Discovery group of the Institute of Structural Biology at the Helmholtz Zentrum München is a platform for structure- and fragment-based drug discovery, which integrates structural biology, NMR methods, computational approaches, and chemical synthesis to develop and apply novel approaches beyond current state-of-the-art for the discovery of new targets and therapeutic small molecules. Therapeutic targets address a range of topics, ranging from diabetes, cancer, lung disease to targets in parasitic diseases and antibiotic resistance.

We seek candidates with interest in translation of structural biology into drug discovery using machine learning techniques. Experience in other structural biology techniques will also be appreciated.

Postdoctoral scientist in computer-aided, structure based drug discovery (f/m/x) 100378

full time

Neuherberg near Munich

Postdocs

Your responsibilities

  • We seek candidates with interest in translation of structural biology into drug discovery using machine learning techniques;
  • The position allows unique opportunity to merge state of the art structural biology and small molecule design by novel tools using Artificial Intelligence;
  • Experimental feedback (Structural biology, NMR, fragment screening, medicinal chemistry) will be used along biochemical methods to validate our computational predictions;
  • Ideally, we are looking for a candidate with proven experience in machine learning models with multidimensional data, with good understanding of computational chemistry;
  • Experience in other structural biology or organic chemistry techniques will also be appreciate.

Your qualification

  • Documented experience of programming in Python;
  • High performance computing skills including knowledge of task parallelisation (utilisation of multiple threads);
  • Knowledge of code optimisation techniques and experience with refactoring;
  • Experience in machine learning model development with Python;
  • Experience in training deep learning models with Keras/Tensorflow.

Desired qualifications

  • Knowledge of highly efficient low-level programming languages (eg. C);
  • Knowledge of object oriented programming languages (eg. C++ or Java);
  • Experience in GPU programming (CUDA);
  • Understanding of linear algebra and 3D geometry;
  • Experience in developing deep learning models from scratch including graph convolutional neural networks and generative models;
  • Experience in computational chemistry/biophysics (quantum molecular mechanics/molecular dynamics methods);
  • Experience in protein bioinformatics and computational structural biology (working knowledge of Biopython);
  • Experience in GUI development, particularly for 3D molecular visualisation.

What we offer you

  • continuous education and training;
  • work-life balance;
  • flexible working hours; and
  • time off in lieu;
  • 30 days annual leave;
  • on-site health management service;
  • mobile work;
  • on-site nursery;
  • elder care;
  • company pension scheme;
  • discounted public transport ticket.

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life world­wide. With its first-class uni­versities and world-leading research insti­tutes it offers an intellec­tually stimulating environment.

Remuneration and social benefits are based on the collec­tive wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to two years, but under certain circum­stances an extension can be arranged.

To promote diversity, we welcome appli­cations from talented people regard­less of cultural back­ground, natio­nality, ethnicity, gender and sexual identity, physical abilities, religion, and age. Qualified appli­cants with physical disabi­lities will be given preference. Please consider the applicant guidance on the Corona pandemic.

Interested?

Apply now by using the 'Apply' button.

If you have further questions, simply contact Robert Schneider, e-mail: robert.schneider@helmholtz-muenchen.de, who will be happy to be of assistance.

Helmholtz Zentrum München

Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Institute of Functional Epigenetics

Ingolstädter Landstraße 1

85764 Neuherberg near Munich

Award for excellent gender equality policy for women and men. Helmholtz Zentrum München is particularly committed to pro­moting professional equality bet­ween women and men. It there­fore aims to increase the proportion of the under­represented sex in the respective field.

The Helmholtz Zentrum München is part of the Helm­holtz Asso­ciation, Germany's lar­gest scien­tific organiza­tion. Altogether 42.000 people current­ly work in its 19 scientific-tech­nical and biological-medical research cen­ters. The Asso­ciation's annual bud­get amounts to around 5 billion Euros.

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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