One of the largest sources of air pollution in today's cities is emissions from transports. Despite stricter directives within the EU, these emissions threaten human health and may cause acute asthma symptoms, lung cancer, and premature death. The harmful health effects of airborne particles are strongly associated with the size of the particles. Nanoparticles, which are the smallest particles (<100 nm), have often shown more toxic properties than larger particles of the same material.
A model of the human lung, a so-called Air Liquid Interface (ALI) system, will be used to investigate the toxicity of nanoparticles in vitro. In this exposure system, cultured lung cells are exposed to airborne nanoparticles in a manner that closely resembles the human inhalation process.
The ALI system will be used to test the toxicity of e.g. exhaust fumes from different fuels and brake wear particles in the laboratory, as well as air pollutants in real world environments, e.g. in a road tunnel. The lung cells will be exposed to primary and aged particles. The airborne particles that enter the ALI system will in principle have the same properties as they have when they are inhaled by humans. The harmful effects of the particles, such as the ability to induce cell death, inflammatory markers and DNA damage, will be investigated in collaboration with the Karolinska Institute.
The project is part of a larger project at EU level, called nPETS, where the smallest nanoparticles will be mapped and characterized in a number of different cities; Barcelona, Milan, Thessaloniki, and Stockholm. The Postdoctoral Fellow will be positioned at the Department of Environmental Science at Stockholm University, but he/she must be prepared to collaborate with researchers from Karolinska Institute and Royal Institute of Technology in Stockholm, and also with researchers in the other European cities participating in the project. The project may involve travelling.
We are seeking a highly motivated Postdoctoral Fellow with interest and experience in experimental toxicology. The position involves toxicity studies of airborne transportation particles using an ALI exposure system in laboratory and real world environments. More specifically the project will involve cell culturing, set-up/development of ALI exposure systems, exposure studies in different environments, testing of several toxicity endpoints, as well as problem solving within these areas, reporting and scientific publication. Guidance of a PhD student, which will be employed by the project, will also be part of the work.
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country.