The Rosalind Franklin Institute is a new National Research Centre, funded by the UK government through UK Research and Innovation, dedicated to promoting transformative changes in life science through interdisciplinary research and technology development. We are currently looking for a Postdoctoral Research Associate to join our Next Generation Chemistry theme’s proteomics team. One of the major goals of all themes is to improve their technologies by a factor of ten. In the case of this project, we want design new gas phase ion chemistries that will allow the development of superior approaches for the characterisation of proteins. Specifically, we want to study ion-ion and ion-photon reactions to inform protein chemistry approaches. The key aspect of this project will be to develop and characterise a versatile new ion trap design. The instrument will be based around a Thermo Exploris 480 that will be modified to contain an additional unique design of ion trap (the omnitrap) that possesses multiple light-, inert gas- and electron- injection approaches for ion reactions and fragmentation. We envisage the discovery of new reactions and fragmentation methodology by exploiting this state-of-the-art bespoke gas-phase ion trap system which will ultimately allow a new phase of protein characterisation as well as chemical proteomics and discovery of new reactions for synthetic biology. We also want to create new approaches to characterise protein post-translational modifications on a proteome-wide scale. The successful candidate will design, develop, characterise, and maintain this bespoke mass spectrometer. You will also use this system with other members of the group in demonstration of proteomic applications.
The project is a collaboration with other themes at the Franklin and with industrial (Thermo and Fasmatech) and academic collaborators, with whom you will work extensively, while liaising with academic experts in the UK and beyond. The post, which is for 3 years in the first instance, reports to the Franklin’s Head of Mechanistic Proteomics, and will work alongside other researchers in the Franklin. Please email informal enquiries to Shabaz.Mohammed@chem.ox.ac.uk.
Closing date: Application accepted until sufficient amount had been received.
Type of Post: Full Time
Period of appointment: 3 years’ fixed term contract in the first instance with a possibility to be extended
Salary: £33,000 - £39,000 per annum
Ref No: 10116