A postdoctoral position is available in the group of Prof. Markus Rüegg at the Biozentrum, University of Basel.
Muscular dystrophies are rare genetic diseases characterized by severe muscle damage caused by the inability of muscle fibers to sustain the mechanical forces generated during contraction. The available position is part of an international research effort aimed to characterize the cellular composition of muscle during disease progression. Mouse models for distinct muscular dystrophies and patient biopsies will be used. In particular, mouse models for LAMA2 MD/MDC1A will be investigated (see: Reinhard et al., (2017). Sci. Transl. Med. 9.; Yurchenco et al., (2018). Matrix Biol. 71-72, 174-187). The project will use single cell-based transcriptomics and proteomics in conjunction with state-of-the-art computational data analysis.
We are looking for candidates with a Ph.D. in molecular biology, biochemistry or neurobiology and a strong background using "omics" technologies. Applicants should be well-trained in advanced cell and molecular biology, have a track record of strong publications and be committed to a career in science. Experience working with mice and the neuromuscular system is a strong plus.