In the collaborative project called “Freezing Hearts” a team of scientists from the four Alliance institutes (UU, TU/e, UMC and WUR) aim to develop potent bio-inspired cryoprotectants to extend heart “life-time” ex vivo. We are looking for an enthusiastic, communicative and highly motivated Postdoctoral Researcher with experience in bio-organic synthesis and quantitative microscopy. Your 3-year project within this collaboration will focus on elucidating and optimizing the structure-activity relationship (SAR) of novel glycopeptide cryoprotectants. The first half of your project will start at UU with the development of a strategy for the efficient synthesis of a range of native and novel modified glycopeptides. The second phase of your project – for what we now expect to be a period of 1.5 years – will be carried out at TU/e, where you will perform an in-depth bio-physical characterization and structure–activity study of the developed glycopeptide derivatives. You will be directly supervised by Dr Tom Wennekes and Prof Ilja Voets, and work intensively with the other Postdoctoral Researcher at UMC and a PhD student at WUR, also hired for the project. Within the project you will use a variety of techniques (solid phase peptide synthesis, chemical and enzymatic synthesis, peptide characterization tools and optical microscopy), and be entrusted with developing and executing experiments, data analysis, presentations and writing manuscripts.
We are seeking a driven, creative and collaborative candidate with a keen interest to learn and the motivation to work in an ambitious and interdisciplinary research team.
You also meet the following essential requirements:
We also would like for you to have previous experience in organic synthesis, solid phase peptide synthesis and peptide characterization and experience in quantitative microscopy including image analysis.