We have a postdoc opening to be hosted in our LBEM@EPFL in the area of structural investigations of biological macromolecules by cryo-electron microscopy (cryo-EM), with a focus on neurodegeneration and Parkinson’s disease.
The project aims to study the structure, function and intracellular mechanisms of several proteins involved in familial forms of Parkinson’s disease, such as alpha-synuclein or LRRK2. Proteins will be expressed and purified on campus and prepared for cryo-EM investigations. Data collection will be done with outstanding in-house equipment, which includes latest generation 300kV instruments, energy filtration and large-area direct electron detectors. Data analysis will be done with extensive IT equipment, using single particle cryo-EM, cryo-electron tomography or CLEM methods.
Candidates should have a Ph.D. in Biology or Physics or related disciplines. The research is expected to involve a combination of some wetlab work, cryo-EM and image processing. Knowledge in cryo-EM sample preparation, data collection and image processing is required.