Postdoctoral Scientist - Neurobiology - Dr Ingo Greger

Postdoctoral Scientist - Neurobiology - Dr Ingo Greger

MRC - Medical Research Council

Cambridge, United Kingdom

Overall purpose:

The successful candidate will work in close collaboration with a Postdoc in the lab with an expertise in patch-clamp recordings, genome editing (CRISPR/Cas-9) and 3D-STORM imaging, as well as with the LMB Light-microscopy team. We also closely collaborate with the Cambridge University on studies of the hippocampal synaptic plasticity mechanisms. In this project, we will characterise signalling and nano-positioning of synaptic/dendritic glutamate receptors under baseline conditions and in response to LTP. LTP will be induced by various means such as 2-photon glutamate uncaging onto individual dendritic spines. Towards this wider aim, we have established various state of the art approaches including 3D-STORM, STED and CRISPR/Cas-9 genome editing. A spare electrophysiology rig will be available to the successful candidate. We also aim to compare native AMPARs to reconstituted recombinant receptors.

Main duties:

  • To undertake research aimed at recording and imaging AMPARs at hippocampal synapses.
  • To identify, develop and apply a broad range of techniques to pursue the research objectives.
  • To present scientific work at seminars within the Laboratory and at external meetings.
  • To contribute to Laboratory-wide discussions on developments within the field.
  • To draft scientific papers, and contribute to the overall preparation of research for publication.
  • To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
  • To assist in the training of PhD Students and other members of the LMB.

Key responsibilities:

  • Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan.
  • To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.
  • To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.
  • To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.
  • To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.
  • To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
  • To enhance your research and generic skills through a tailored development programme.

Academic qualifications:

These should include a PhD in a relevant subject or due to complete PhD within 6 months.

Technical skills and expertise:

Experience of and ability to perform techniques relevant to the project. Particularly useful would be some of the following:

Essential:

  • Strong expertise in patch-clamp electrophysiology.
  • Expertise with brain slice recordings.
  • Expertise in basic imaging approaches.
  • Molecular Biology techniques.

Desirable:

  • Interest in ion channels and synaptic physiology.
  • Experience with super-resolution light microscopy approaches.
  • 2-photon microscopy.
  • Genome editing.
  • Expertise with cell culture.
  • Expertise with handling rodents.

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© EuroJobsites 2020

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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