Postdoc in Systems and Synthetic Biology of Host-Microbiome Interaction

Postdoc in Systems and Synthetic Biology of Host-Microbiome Interaction

KTH - Royal Institute of Technology

Stockholm, Sweden

Job description

The progression of conditions such as chronic kidney disease (CKD), liver cirrhosis (LC) and Crohn’s diseases (CD), could be the mediation of interplays between different host tissues, and microbiome. Changes in diet, medication (such as antibiotics), and microbiome could impact the host physiology towards more progression in chronic conditions and also changes in the gut that impair barrier function and release of microbial metabolites, live microorganism and residue into the circulation. Thus, investigating the whole-body multi-omics in the chronic conditions and targeted therapies are the way forward.

Here, we take a holistic approach to understand the role of different tissues and microbiome, together with diet to elucidate the interactions between them. We investigate the relationship between fibrosis process, inflammation, metabolism and microbiome using multi-omics data in CD, CKD & LC. We are now seeking one postdoc with strong skills to first work on performing multi-omics analysis to understand the diseases progression. Second, we aim to develop CRISPR-based method to modify the microbiome targeted to attack specific pathogens as potential future therapy instead of antibiotic administration and overcome resistance. In addition, the post could contribute to the expansion of our recently developed human microbiome atlas.

Qualifications

The candidate is expected to perform research in Molecular, Computational and Synthetic Biology in host and microbiome area with a relevant PhD subject. Degree must have been completed no more than three years before the application deadline.

We are looking for a scientist with the following qualifications:

  • Proven record within molecular and systems biology, experience with multi-omics data analysis and integration;
  • Experience with CRISPR technology, developing vectors for simultaneous targeted insertion in multiple genomic sites.

Requirements

  • A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline.

Preferred qualifications

  • We prefer that the candidate have a strong background in systems biology, molecular biology methods, CRISPR technology, omics analysis and statistics. The candidate should be highly motivated for doing scientific research related to human diseases and should have well developed analytical and problem-solving skills. Additionally, the candidates should have excellent written, oral communication skills;
  • You possess scientific skill and good pedagogical ability. You have good collaboration and can work independently. You are well aware of diversity and equal treatment issues with a special focus on gender equality;
  • Great emphasis will be placed on personal competence and suitability.

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EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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