The German Center for Neurodegenerative Diseases (DZNE) is a unique non-university research center which is dedicated to the subject dementia and all its areas, as well as other neurodegenerative diseases. The center compasses the full spectrum of fundamental research through population sciences to health care research. The DZNE stands for excellence in research and science management, translation of scientific results into practice, interdisciplinarity and internationalization. It is a research center within the Helmholtz Organization of German research centers. With over 1,000 employees from 55 nations, spread over 10 sites, the DZNE is one of the national and international leading research centers in its research field.
The DZNE in Dresden advertises a PhD Studentship (f/m/d) Electrophysiological methods for deciphering large-scale activity-dependent neuroplasticity.
The laboratory of plasticity models for aging and neurodegeneration offers a PhD position for an outstanding candidate to study the activity-dependent plasticity changes (from circuits to network) in large-scale neurogenic models. The research will be carried out at the German center for neurodegenerative diseases (DZNE) in Dresden, Germany. The major objective of our lab is to examine groundbreaking questions on the functional and molecular role of newly-generated neurons in the adult brain. Using a variety of modern techniques (molecular and cellular biology, electrophysiology, genetics, opto-/chemogenetics, modeling, and neurocomputation), the aim is to discover the interaction across multiple forms of plasticity (functional and molecular) in new-born neurons and to characterize how this plasticity shapes information processing in neuronal circuits and networks. This is not only relevant in a healthy context but, in particular, at the early stages of neurodegeneration, when networks still can respond and be capable of reserve formation and recompense functions.
We are building a truly interdisciplinary research unit where experimental neuroscience, theory, and engineering expertise team up to foster advances in neuroscience and neurotechnologies. Join us and be one of the first ones using cutting-edge neurotech to improve the use of newly-generated neurons in the brain to stall aging and neurodegeneration. For more information on our research, check our lab page (www.dzne.de/amin).
This PhD position is aimed to conduct and analyze multimodal multiscale experiments (molecular, cellular, and network) to understand the mechanisms of the functional plasticity by tackling the functional brain readouts from circuits to networks. These experiments will use a combination of modern approaches, including in-vitro and ex-vivo electrophysiology (high-resolution multielectrode arrays and patch-clamp recordings), Imaging-based assay, and opto-/chemogenetics. The aim is to obtain a fundamental understanding of neural regeneration circuitry and leveraging this for providing better disease models and novel treatments for neurodegenerative diseases. The successful candidate will take part in all aspects of the project, from experimental design, data generation, analyses, interpretation and writing of the manuscript.
Please send your application in a single pdf file (in English) including:
The application should be sent via this link as soon as possible but before February 15th, 2020. Review of applications will begin immediately and continue until the position is filled.
Neuroscience, adult neurogenesis, neurodegeneration, neuroplasticity, electrophysiology, neuronal circuits, and networks.