Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres

Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Overall purpose:

To work within the Group of Dr Sjors Scheres at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at the structural characterisation of amyloid filaments involved in neurodegenerative disease. Specifically, to undertake research to investigate the relationship between the structure of tau and alpha-synuclein filaments and their ability to spread through the brain. The work will involve purification of filaments from human brain tissue as well as reconstitution of filaments in vitro, and their subsequent structural characterisation with cryo-electron microscopy. Handling of human tissue and "functional" characterisation will be done in close collaboration with the group of Dr Michel Goedert, and possibly also with the group of Dr Ben Falcon, who are both also at LMB.

Main duties:

  • To undertake research aimed at characterising the structure of amyloid filaments, and their ability to spread through the brain;
  • To identify, develop and apply a broad range of techniques to pursue the research objectives;
  • To present scientific work at seminars within the Laboratory and at external meetings;
  • To contribute to Laboratory-wide discussions on developments within the field;
  • To draft scientific papers, and contribute to the overall preparation of research for publication;
  • To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care;
  • To assist in the training of PhD Students and other members of the LMB.

Key responsibilities:

  • Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three year lifespan;
  • To plan your own work and objectives on a 12 month basis and manage your experimental work within the project along with your Supervisor;
  • To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project;
  • To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required;
  • To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements;
  • To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities;
  • To enhance your research and generic skills through a tailored development programme.

Working relationships:

  • You will report to Drs Sjors Scheres and Michel Goedert and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Person Specification:

Academic qualifications:

  • These should include a PhD in a relevant subject or due to complete PhD within 6 months.

Technical skills and expertise:

  • Essential: An affinity for biophysical methods and numerical data analysis;
  • Desirable: Experience in the biophysical/biochemical characterisation of amyloid filaments or experience in experimental cryo-electron microscopy are important advantages.

Track record of research:

  • This will include achievements, and contributions to published papers.

Other relevant evidence of:

  • Commitment;
  • Originality;
  • Ability to communicate;
  • Working with others.

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© EuroJobsites 2019

EuroJobsites is a registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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