The laboratory is looking for a highly motivated postdoctoral researcher to investigate and characterize the interplay between endocytic events at the plasma membrane and autophagosomal degradation in Arabidopsis. Recent observations show that over-expression of AtEH1 or AtEH2, both members of the octameric TPC, induces an autophagy pathway in planta. In addition, several players of the endocytic machinery, including AP-2 and TPC subunits, as well as clathrin, are recruited to these autophagosomes and delivered to the vacuole (Wang & Pleskot et al., under revision at Nature Communications).
The current project aims to characterize this newly identified degradation route in detail as well as mechanistically elucidate the role of the TPC and the endocytic machinery in this pathway (e.g. as cargo and/or as machinery). This will also include combining high-end interactomics and cell biological approaches to determine the cargo proteins as well as their origin.
The position is immediately available, with the exact start date to be negotiated with the suitable candidate.