We would like to understand the cell-cell interactions within the liver module (Kupffer cells, Endothelial cells, Stellate cells and Hepatocytes). How do these cells talk to one another? What cell-cell circuits are present in the healthy liver? Which receptors are involved and what transcription factors do these receptors induce? What functional gene modules are these transcription factors controlling? What is the homeostatic function of these cells within the liver module? Can we use the knowledge of homeostatic cell-cell circuits to boost tissue regeneration?
We are seeking highly motivated and dynamic individuals with a strong passion for macrophages and a formidable team-spirit. Previous experience in immunology, developmental biology, cellular biology, hepatology, organogenesis, single-cell technologies and/or epigenetics are strongly recommended.