Within a joint collaboration of the two partner labs, the 2-years post-doc position is located in the ultrafast spectroscopy lab (BIODYN, Pr. S. Haacke) in Strasbourg. Our group studies femtosecond photo-chemistry in retinal proteins and other biomolecules using state-of-the-art laser facilities and home-built set-ups (TAS, fluorescence, 2DES). The research project implies adaptation of these set-ups for micron-sized protein crystals, in particular of retinal proteins (e.g. bR). In addition, a detailed characterisation of multi-photon absorption cross sections as a func-tion of excitation wavelength is a challenging but mandatory task, never performed for protein crystals. Regular exchange with the MPI team (“Biomolecular Mecha-nisms”, Dr. I. Schlichting) will take place concerning crucial expertise in protein crystal handling and delivery as well as X-ray crystallography. Participation in XFEL experiments is expected. Besides, the early career scientist will independently pursue new research ideas, publish exciting papers and publicize his/her work at conferences, mentor graduate students, and participate in fundraising efforts.
The work is a follow-up of our previous publication reporting X-ray crystallography under high excitation conditions for bacteriorhodopsin (Nass Kovacs et al. Nature Comm., 10, 3711 (2019)) and will extend to other proteins such as haemoglobin. The next challenge is to perform these experiments for laser excitation in optimised single photon conditions occurring in Nature.
Doctoral Degree in a related field (Physics, Chemistry, Photonics) and demonstrated research ability. Preferred applicants should have a strong background in ultrafast optics, (bio-) molecular and possibly protein spectroscopy. We like to work with team players and young enthusiastic scientists attracted by a broad interdisciplinary horizon, and an international collabo-ration.
A preferred candidate should have 2 years of research experience in the field of ultrafast optics and spectroscopy. Experience with protein expression and handling, data analysis, and new technical developments, including software, are a plus. Starting date: As soon as possible.