Postdoctoral Scientist - Structural Studies - Dr Kelly Nguyen

Postdoctoral Scientist - Structural Studies - Dr Kelly Nguyen

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Job Description

Overall purpose:

To work within the Group of Dr Kelly Nguyen at the MRC Laboratory of Molecular Biology (LMB) on a programme investigating molecular mechanism of telomere maintenance in yeast. The project will involve developing biochemical methods to isolate macromolecular complexes involved in this process and visualise them using cryo-electron microscopy.

Main duties:

To study how telomeres are maintained in yeast and will involve:

  • Development biochemical methods to isolate complexes from yeast.
  • Characterisation of these complexes using a range of biochemical and biophysical assays.
  • Cryo-EM grid preparation, data processing and structural determination of these complexes.
  • In vivo functional studies to validate the structures.
  • To identify, develop and apply a broad range of techniques to pursue the research objectives.
  • To present scientific work at seminars within the Laboratory and at external meetings.
  • To contribute to Laboratory-wide discussions on developments within the field.
  • To draft scientific papers, and contribute to the overall preparation of research for publication.
  • To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
  • To assist in the training of PhD Students and other members of the LMB.

Key responsibilities:

  • Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three year lifespan.
  • To plan your own work and objectives on a 12 month basis and manage your experimental work within the project along with your Supervisor.
  • To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.
  • To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.
  • To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.
  • To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
  • To enhance your research and generic skills through a tailored development programme.

Working relationships:

You will report to Dr Kelly Nguyen and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Person Specification

Academic qualifications:

  • These should include a PhD in Molecular Biology or related field.

Technical skills and expertise:

Essential:

  • Experience of and ability to perform techniques relevant to the project. Particularly useful would be experience in molecular biology, protein/nucleic acid biochemistry, protein expression and purification, structural biology (either X-ray crystallography or cryo-electron microscopy).

Desirable:

  • Experience in yeast genetics, cell biology, eukaryotic cell cultures.

Track record of research:

  • This will include achievements, and contributions to published papers.

Other relevant evidence of:

  • Commitment.
  • Originality.
  • Ability to communicate.
  • Working with others.

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© EuroJobsites 2019

EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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