The overall aim of this project is the development of interconnected nanocompartments to serve as a platform for regenerative medicine. Synthetic compartments decorated with single strands DNA will be self-organized in clusters via DNA hybridization and loaded with specific biomolecules to trigger a bio-reply in cells. A particularly important part of the project will intend to decorate the clusters with different DNA strands and evaluate their overall architecture and interaction with cell lines. In addition, structural characterization and functionality assays of the biomolecules encapsulated in the nanocompartments represent a prerequisite for development of such functional platform for regenerative medicine.
This is an interdisciplinary project within the National Centers of Competence in Research "Molecular Systems Engineering" from which you will gain valuable experience in the domain of nanoscience, physical chemistry, biochemistry, and regenerative medicine approaches. Your role will be to selfassembly the compartments, load them with biomolecules and control them to form stable clusters that specifically interact with cells.