Scientist Process Development (Downstream)

Batavia Biosciences

Scientist Process Development (Downstream)

Batavia Biosciences

Woburn, MA, United States

Company Profile

Batavia Biosciences is a CDMO specializing in the development and manufacture of viral and vector-based vaccines for global health. With sites in Leiden, The Netherlands and Woburn, USA, the company actively participates in major global health initiatives where we collaborate with funding organizations like BMGF, PATH, CEPI and IAVI, Innovative biotech, large pharma and developing country vaccine manufacturers to help bring more affordable vaccines to the market. We have a strong internal focus on developing unique technologies and know-how that can be applied to further our goal of accelerating development of low-cost vaccines.

The position

We are looking for a Scientist experienced in downstream processing for viral vectors to join our Viral Vector Process Development team in Woburn, MA.

The person will join a multi-functional team responsible for all aspects of viral vector process development from generation of the viral vector pre-Master Virus Seeds to development of the upstream and downstream manufacturing process, development of the analytical assays, preparation of GMP documentation and tech transfer, either to our Leiden GMP facility or to a partner such as a developing country vaccine manufacturer.

The downstream development group is responsible for development of GMP grade processes for a range of viral and vector-based vaccines including AAV, Adenovirus, VSV, CMV and Lentivirus using cell lines including VERO, MRC-5 and HEK293. A close collaboration within the team between upstream, downstream, vector generation and analytical personnel is required. Additionally, there will be close collaboration with the Netherlands site as projects may be run over both locations.

In our startup culture, the ideal candidate will show entrepreneurial spirit, independence and ability to take strategic, calculated risks to guarantee efficient progression of the projects and help build the team and the US operations. This innovator will be motivated by assessing and implementing new manufacturing technologies to keep Batavia ahead of the competition. Agility, flexibility and will to contribute to projects that have a strong impact on global health are key components of the culture of Batavia Biosciences.

RESPONSIBILITIES:

  • Technical leadership in the development of scalable, robust, high yielding, and economically viable purification processes for a range of viral vectors including AAV, Adenovirus, VSV, CMV and Lentivirus. Processes will be developed at bench scale and scaled-up to Ph.I/II clinical scale prior to tech transfer. Knowledge of process monitoring and control strategies, Design-of-Experiments experimental set up and different process technologies including clarification, tangential flow filtration, UF/DF, column chromatography and final filtration;
  • Experience with viral process validation and scale down models, including review and interpretation of results;
  • Experience with process scale-up;
  • Process documentation suitable to allow tech transfer to GMP manufacturing (within Batavia or to external manufacturer);
  • Collaboration and coordination with other teams including upstream process development, analytical development and formulation development;
  • Manage, train, guide and coordinate activities of junior staff members;
  • Participate in and provide information to project team meetings;
  • The position may entail travel to other Batavia sites or tech transfer recipients.

EDUCATION AND EXPERIENCE:

  • B.S./M.S. or Ph.D;
  • 5+ years (B.S./M.S.) or 3+ year (Ph.D.) of related experience working in biopharmaceutical industry focusing on viral vaccine or viral vector purification;
  • Hands on experience in developing and optimizing scalable viral vaccine or vector-based purification processes including knowledge of process scale-up/scale-down, process validation and aseptic processing;
  • Experience operating in early and late stage clinical process development, ideally with experience of contract development and manufacturing;
  • Ability to adapt to change and effectively deliver under pressure while maintaining a high level of work quality;
  • Strong verbal and written communication skills and ability to communicate within the organization. Strong process documentation skills;
  • Ability to use DoE in Design Expert, or other for statistical experimental design, data analysis and knowledge of statistical process control, QbD, and PAT concepts.

You will join a stimulating and international team working in a highly collaborative environment within global consortia. As part of this group, personal as well as scientific growth are encouraged and developed. In this position, you will report to the Director of Viral Vector Process Development.

Please send applications to Mrs. Ingrid van Aarle, HR Manager, by e-mail recruitment@bataviabiosciences.com.

Don't forget to mention EuroScienceJobs when applying.

Share this Job

More Job Searches

Outside Europe     Chemical Engineering     Chemistry     Commercial     Maths and Computing     Pharmaceutical     Statistics     Batavia Biosciences    

© EuroJobsites 2019

EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

Newsletter | Recruit | Advertise | Privacy | Contact Us

© EuroJobsites 2019

EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

This website uses cookies to make your experience better. Continued use of this website means you accept our cookie policy.  Accept Cookies