Two post-doctoral positions are available in the Dejean Laboratory, Nuclear Organisation and Oncogenesis Unit, to study the role of SUMOylation in the epigenetic mechanisms governing cellular identity in normal and disease cells. Cellular identity is dictated by large transcriptional programs mediated by specific chromatin configurations, yet the mechanisms by which cell fate transitions are normally constrained, or corrupted in disease, remain poorly understood. Identifying barriers to cellular plasticity is thus of key interest to dissect lineage choice mechanisms during development and has important clinical implications. While the contribution of DNA methylation and histone modifications during cell fate change has been extensively studied, the role of post-translational modifications of proteins by other proteins in this process is still enigmatic. Our lab has recently shown that, among these, SUMOylation is a key chromatin-associated mark that acts as a general safeguard of cellular identity. The project aims to clarify the role of SUMOylation in chromatin biology and cell plasticity and to analyze the possible impact of dysregulating this pathway in cancer and muscle regeneration.
Candidates should have proven research skills in epigenetics and protein biochemistry. Experience in cancer biology, tissue repair and/or computational biology will be a plus.