The Tumour Cell Death group is a vibrant team which aims to understand how cell viability is controlled during tumour development and in response to cancer therapy. We focus on apoptosis and autophagy – two pathways that control cell viability – and we study both existing and novel factors controlling these pathways. We are interested in the basic molecular mechanisms of apoptosis and autophagy, coupled with the use of in vivo cancer models to understand the impact of these pathways on the establishment, maintenance and spread of cancer. Ultimately, our studies aim to provide insights to both improve existing clinical regimens and to identify novels targets for therapeutic intervention.
Applicants must have a PhD in a relevant field, be ambitious and be driven by scientific curiosity. Existing skills with regard to mammalian cell culture and molecular biology are desired and experience of immunology and/or in vivo cancer models would be an advantage, but is not essential.